![]() ![]() Thus, proving that the homeobox genes of Otx2 are essential in forming a viable embryo. It was found that without the Otx2 gene expression there was slow degeneration of photoreceptor cells in this area. A “ knockout” model on the group of Otx2 genes has been performed to see what effects it would have on the adult retina. Otx2 mutations have also been associated with seizures, developmental delays, short stature, structural abnormalities of the pituitary gland, and an early onset of degeneration of the retina. This group of genes has a huge role in development and if it is expressed incorrectly it can have detrimental effects on the fetus. Otx2 not only has a prominent role in developing this area but also aids in ensuring that the retina and brain stay intact. ![]() This group of genes demonstrates later in progression to have an influence on the formation of the sensory organs, pituitary gland, pineal gland, inner ear, eye and optic nerve. Otx2, which is an encoded protein that plays the role of a transcription factor, has also been shown to be involved in the regional patterning of the midbrain and forebrain. Otx2 is a group of homeobox genes that are typically described as a head organizer in the primitive streak stage of embryonic development. Other alternative splice variants may exist, but their full length sequences have not been determined. Two transcript variants encoding distinct isoforms have been identified for this gene. A similar protein in mice is required for proper forebrain development. The encoded protein acts as a transcription factor and play a role in brain and sensory organ development. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. Homeobox protein OTX2 is a protein that in humans is encoded by the OTX2 gene. positive regulation of transcription by RNA polymerase II.positive regulation of embryonic development.regulation of smoothened signaling pathway.positive regulation of transcription, DNA-templated.regulation of fibroblast growth factor receptor signaling pathway.regulation of transcription, DNA-templated. ![]()
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